It is quite strange, but sometines I find nice and even funny acronyms for R&D projects, scientific instruments, concepts, etc.
In a recent Discover magazine article (it can be found HERE) a Section was called "MACHOs aren't the answer".
In this case, MACHOs stands for Massive Compact Halo Objects and the author wanted to say that these objects do not satisfactorily explain the great rotation speeds that stars at a galaxy's edge have.
I know of some other acronyms, but I prefer to keep them for myself :-)